Main interest:
o Solubility and stability of pharmaceuticals in the gastrointestinal tract
o Degradation of the active compound or activation of pro-drugs by
digestive or fermentative processes
o Absorption of active compound from the gastrointestinal tract
ProDigest focus:
o Bioavailability of the active compound is the key focus
- Stability in the gastrointestinal tract
- Degradation in the stomach and small intestine
- Microbial metabolism in the colon
- Solubility of the formulation
- Permeability of active compounds
o Services:
- Small-scale in vitro experiments (passage through stomach and
small intestine, solubility, microbial metabolism)
- Absorption models
- SHIME experiments: short and long term evaluation of the
intestinal fate of specific compounds or formulations
- Pharmacokinetic validation of bioavailability in laboratory animals in
collaboration with third parties